Communicating science with art: how are we and fish alike?

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Capital News Service

LANSING — We like fish. 

And we are like fish. 

Two Michigan State University scientists recently displayed that similarity through art.

Ingo Braasch and Julia Ganz, assistant professors in the university’s Department of Integrative Biology, compiled videos and photos taken during their research into artwork named “Life in Technicolor: The Art of Fish Development and Evolution.” They showed it at a recent MSU science-art exhibition.

The art is a byproduct of differentiating types of cells to better study them.

“Vertebrates are the animals with a backbone,” Braasch said. “We are vertebrates. So are fish.” 

In an early embryo, a subgroup of cells migrates around the developing body and generates different types of cells, he said. Some develop into teeth, skull or parts of the heart. These are called neural crest cells. 

“What makes vertebrates unique are their neural crest cells,” Braasch said. “They make all the different structures, including what we showed in our artwork.”

Ganz’s artwork depicts the enteric nervous system in the gut, which can control the gut movements.

“It has a cool name as ‘the second brain’ because it can work independently from the central nervous system,” Ganz said. “If you take out a gut and cut down all its connections to the central nervous system, it would still function on its own.”

To study the workings of neural crest cells and the enteric nervous system, the scientists do research that produces art as a byproduct.

Some of the images depict the neuron network of diverse types of cells in a fish’s gut. Ganz differentiated them by applying fluorescence staining, a technique that allows them to illuminate various proteins and cells in different colors. 

“Simply speaking, we make certain proteins and cells glow to produce the images,” Ganz said.  

Braasch looked at pigment cells under the microscope and took pictures of them. 

“In mammals like us, there’s only one type of pigment cell, the melanocytes,” Braasch said. “They produce the pigments that are red, brown, blond or black. These pigments determine the colors of our skin and hair.”

But fish have many types of pigment cells, Braasch said. Some fish make a silvery shiny cell that reflects light. Others can stack different pigment colors on top of each other to produce even more colors. 

“It’s like nature is an artist and can paint like Monet,” Braasch said. “What I want to show is that the fish have different beautiful colors because of the diversity of their pigment cells.”

Normally, the gar looks brown and black. 

“But in several of these pictures, I took away the black pigment so we can see the other pigment cells,” Braasch said.

It’s weird to think about how the cells that make our second brain also make our pigmentation, Brassch said. Although they’re completely different in what they do, they share the common ancestry in the embryo. 

Studying fish teaches us about ourselves, the researchers said.

“Both of our research goals are to do basic research in fish,” Ganz said. “We use their experimental advantages to have findings that can then be translated into mammals and humans.”

Ganz focuses on basic research to study some human enteric nervous system diseases.

For example, Ganz has discovered that the enteric nervous system promotes intestinal health in zebrafish. The knowledge could contribute to a successful cure of Hirschsprung’s disease, one of the most severe examples of enteric nervous system dysfunction in humans.

“We want to show that images taken in our research can be beautiful and cool,” Ganz said. “And we hope that the artwork might trigger people’s curiosity about science and inspire them to figure it out.”

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